Characterisation of tumour microenvironment

Characterisation of the role of pro-inflammatory cytokines and their receptors in the remodelling of the tumour microenvironment and in breast cancer progression.

Pro-tumoral inflammation in metastasis

Elucidation of the role of pro-tumoral inflammation in metastasis and the possible implications of blocking this signalling to improve the response to immunotherapy.

Resistance to hormonal therapies

To understand the molecular mechanisms that mediate resistance to hormonal therapies in luminal breast cancer, which accounts for more than 70% of diagnosed cases. Anti-estrogen treatments are the backbone of the treatment of these patients and resistance to these treatments is an unsolved problem with a high therapeutic impact.